A new kind of AIE molecules with excellent PDT effect in the cancer treatment were developed, which can induce the cell apoptosis in 15 seconds upon light illumination. Simultaneously, the increasing in the fluorescent signal readout could quickly evaluate its therapeutic response in situ. Such a single molecule that can not only execute effective PDT therapy but also report back on its efficacy in real time, is of great significance to evaluate and guide the therapy.

   The characteristics of the Sustained Drug Release Platform. A): The Cumulative DOX release from DOX-loaded LLC gel; B and C is the cross polarized microscope image of Lyotropic Liquid Crystalline Gels  with different ratio (b: SPC:GDO = 50:50; c: SPC:GDO = 70:30).Scale Bar :100μmThe characteristics of the Sustained Drug Release Platform. A): The Cumulative DOX release from DOX-loaded LLC gel; B and C is the cross polarized microscope image of Lyotropic Liquid Crystalline Gels  with different ratio (b: SPC:GDO = 50:50; c: SPC:GDO = 70:30).Scale Bar :100μm

   Studies have shown that lentinan can inhibit the aggregation of human amylin. The results show that lentinan could reduce the fluorescence signal of ThT and inhibit the fibrosis of hIAPP. In particular, when the triple helix structure of LNT exists, the inhibitory effect is more obvious. What is more, lentinan with a triple helix structure can prevent hIAPP from producing toxic oligomers and inhibit its cytotoxicity against INS-1. Therefore, lentinan as a potential drug for the treatment of type 2 diabetes is of great significance.